The smell of bubbling cheese and savory meat sizzling in the oven transports me back to cozy family dinners from my childhood. On those busy weeknights, all I craved was a warm, comforting meal that came together effortlessly, and that’s when I discovered the magic of Bubble Up Pizza Casserole. This crowd-pleaser is not only high-protein but also customizable to satisfy even the pickiest eaters at your table. With just six simple ingredients, you can create a hearty dish that brings everyone together, making it perfect for quick dinners or meal prepping for the week ahead. Ready to explore how this Pizza Casserole with Biscuits and Cheese can make your evening meals a breeze? Let’s dive into the simple steps that will fill your kitchen with warmth and joy!
Why is Pizza Casserole a Family Favorite?
Comforting, Hearty Dish: This Pizza Casserole with Biscuits and Cheese is the ultimate love letter to comfort food, blending gooey cheese with savory meat that transports you back to family gatherings.
Quick to Prepare: With just six ingredients, you’ll have a delicious meal ready in no time, perfect for busy weeknights or quick meal preps.
Kid-Approved: The cheesy goodness and fun biscuit texture make it a hit with kids, ensuring even the pickiest eaters will smile at the dinner table.
Customizable to Your Taste: Feel free to swap in your favorite veggies or protein options, letting everyone build their perfect slice in a casserole form! Pair it with a fresh salad for a balanced meal.
Make-Ahead Friendly: Prepare it in advance and refrigerate, making weeknight dinners a breeze without sacrificing flavor! Enjoy the ease and warmth it brings to your family meals.
Pizza Casserole with Biscuits and Cheese Ingredients
For the Casserole
• Lean Ground Beef – This hearty protein helps create a filling base; substitute with turkey or chicken for a lighter option.
• Bell Peppers – These colorful veggies add nutrients and crunch; they can be omitted or swapped for mushrooms if preferred.
• Pizza Sauce – A must-have for that classic pizza flavor in your casserole; choose no-sugar-added varieties for a healthier twist.
• Pillsbury Grands Biscuits – Essential for forming fluffy layers; gluten-free biscuit options are available if needed.
• Shredded Mozzarella Cheese – The star ingredient that melts beautifully; feel free to switch it up with cheddar or dairy-free cheese.
• Sliced Turkey Pepperoni – This flavorful addition contributes protein and zest; it can also be replaced with regular pepperoni or omitted for a veggie option.
Step‑by‑Step Instructions for Pizza Casserole with Biscuits and Cheese
Step 1: Preheat the Oven
Begin by preheating your oven to 375°F (190°C) to ensure it’s perfectly hot when your Pizza Casserole with Biscuits and Cheese is ready to bake. While the oven heats, grease a 9×13 inch baking dish with non-stick spray or a little olive oil to prevent sticking and help create a golden crust.
Step 2: Cook the Ground Beef
In a large skillet, heat over medium heat and add the lean ground beef. Cook for approximately 3-4 minutes, breaking it apart with a spoon until it is crumbled and no longer pink. Season the beef with salt and pepper to taste, giving it delicious flavor as it cooks. Once done, drain any excess fat before moving on to the next step.
Step 3: Sauté the Vegetables
Add the diced bell peppers to the skillet with the cooked beef, and stir well. Sauté them for about 3-5 minutes until the peppers soften and become fragrant. Once tender, drain any liquid that has accumulated in the pan and stir in the pizza sauce, warming it briefly to meld the flavors together before incorporating it into the casserole.
Step 4: Prepare the Biscuits
While the beef and vegetables are cooking, take the Pillsbury Grands Biscuits and cut each one into six even pieces. This will help form the fluffy base of your Pizza Casserole with Biscuits and Cheese. Layer these biscuit pieces evenly across the bottom of your greased baking dish, ensuring they are spread out for even cooking.
Step 5: Combine the Mixtures
Next, pour the beef and vegetable mixture over the biscuit pieces in the baking dish, ensuring an even distribution. Gently fold the beef mixture into the biscuit pieces so that they are well combined. This step will create a hearty union of textures and flavors in your casserole, making it wonderfully rich and satisfying.
Step 6: Add Cheese and Pepperoni
Sprinkle a generous layer of shredded mozzarella cheese over the top of the casserole. Follow it up by adding sliced turkey pepperoni for an extra punch of flavor. Make sure to cover the entire surface for that gooey, cheesy finish that defines this Pizza Casserole with Biscuits and Cheese.
Step 7: Bake the Casserole
Place the baking dish in the preheated oven and bake uncovered for 25-30 minutes. Keep an eye on it, watching for the biscuits to become bubbly and golden brown. If they start to brown too quickly, you can loosely cover the casserole with foil to prevent over-browning while allowing it to cook through.
Step 8: Cool and Slice
Once the baking time is up, remove the casserole from the oven and let it cool for 5-10 minutes. This cooling period allows the flavors to set and makes slicing easier. When ready, use a sharp knife to cut into portions, serving up warm bites of your delightful Pizza Casserole with Biscuits and Cheese.
Pizza Casserole with Biscuits: Delightful Variations
Feel free to get creative with your Pizza Casserole; there are so many ways to add your personal touch!
-
Lean Protein: Substitute ground beef with turkey or chicken for a lighter version. It’s a simple swap that maintains the beloved heartiness of this dish.
-
Veggie Boost: Add diced zucchini, spinach, or mushrooms to the beef mixture for an enhanced nutrient profile. These extra veggies not only boost flavor but also add delightful textures.
-
Spicy Kick: Incorporate sliced jalapeños or red pepper flakes to the casserole for an extra layer of heat. This will liven up each bite, making it perfect for spice lovers.
-
Dairy-Free Delight: Use dairy-free cheese or omit cheese altogether for a lactose-intolerant friendly option. This slight tweak is perfect for everyone to enjoy without missing out on flavor.
-
Italian Twist: Try swapping regular pizza sauce for pesto for a unique flavor profile. This fragrant alternative adds a refreshing touch that’s sure to impress.
-
Creative Toppings: Mix in or top with olives, artichokes, or sun-dried tomatoes for a gourmet twist. Elevate the dish, infusing it with Mediterranean-inspired flavors.
-
Vegetarian Version: Omit the meat entirely and replace with more veggies or even cooked quinoa. It’s a filling alternative that guarantees satisfaction without the protein.
-
Gluten-Free Alternative: Replace the Pillsbury Grands Biscuits with gluten-free biscuit options for everyone to enjoy this casserole without hesitation. It makes the dish accessible to more tables.
Let’s whisk up those family dinners or use these variations for a fun mealtime adventure! If you need more inspiration, don’t forget to check out my Chicken Stuffing Casserole or Southern Squash Casserole for more cozy options!
How to Store and Freeze Pizza Casserole with Biscuits and Cheese
Fridge: Store leftovers in an airtight container for up to 3-4 days. Ensure it’s completely cooled before sealing to maintain freshness.
Freezer: To freeze, portion the Pizza Casserole with Biscuits and Cheese into airtight containers or freezer bags. It will keep well for up to 3 months.
Reheating: For best results, thaw in the fridge overnight, then reheat in the oven at 350°F (175°C) until heated through. Microwave reheating is also an option, though it may affect texture.
Assembly Tip: Consider assembling the casserole partway in advance and freezing before baking. It can go straight from the freezer to the oven, making meal prep a breeze!
Make Ahead Options
These scrumptious Pizza Casserole with Biscuits and Cheese are the ideal solution for busy cooks looking to save time during the week! You can prepare the entire casserole up to 24 hours in advance; simply assemble it in the baking dish, cover tightly, and refrigerate. To maintain quality, remember to drain any excess moisture from the meat and veggie mixture before adding it to the biscuits. When you’re ready to bake, preheat your oven and pop the casserole in directly from the fridge, adding an extra 5-10 minutes to the baking time. This way, you’ll have a comforting meal that comes together effortlessly, perfect for those hectic weeknights!
Expert Tips for Pizza Casserole with Biscuits and Cheese
-
Drain Excess Liquid: Properly draining the beef and bell pepper mixture is crucial to avoid a soggy casserole that doesn’t hold its shape.
-
Achieve Crispy Biscuits: For a delightful golden crust, broil the casserole for a few minutes at the end of baking. Just keep an eye to prevent burning!
-
Meal Prep Magic: Assemble the Pizza Casserole with Biscuits and Cheese in advance, and store it in the fridge for a quick dinner option on busy nights.
-
Season to Taste: Don’t forget to taste your beef mixture before adding it to the casserole. Adjust salt and pepper as needed for the perfect flavor.
-
Easily Customize: Feel free to swap proteins or veggies in your casserole. This flexibility lets you delight picky eaters while keeping it nutritious!
What to Serve with Bubble Up Pizza Casserole
Elevate your dining experience by pairing this cheesy delight with sides that bring out its comforting flavors.
-
Garlic Bread: The crispy, buttery texture complements the gooey casserole and adds a delightful crunch.
-
Caesar Salad: A fresh, crisp salad cuts through the richness, providing a refreshing contrast to the warm, savory casserole.
-
Steamed Broccoli: This vibrant green addition adds nutrients and color, balancing the meal with a light, healthy element.
-
Mozzarella Sticks: Indulge in a cheesy theme; these sticks provide extra gooeyness that pizza lovers will adore.
-
Coleslaw: This tangy, crunchy side brings brightness and a refreshing crunch, enhancing the overall meal experience.
-
Fruit Salad: A sweet, fruity interlude lightens up the meal, offering a burst of freshness and natural sweetness.
-
Sparkling Water: A bubbly drink helps cleanse the palate and complements the savory dish beautifully.
-
Chocolate Chip Cookies: Finish with a sweet treat that pairs perfectly with the warm, cheesy casserole for a comforting end to your meal.
Pizza Casserole with Biscuits and Cheese Recipe FAQs
How do I choose ripe bell peppers for my casserole?
Absolutely! Look for bell peppers that are firm and have vibrant, glossy skins. Avoid any with dark spots or blemishes. If they’re slightly wrinkled, that may indicate they are past their prime. Fresh, brightly colored peppers will enhance both the flavor and appearance of your Pizza Casserole with Biscuits and Cheese.
What is the best way to store leftovers?
After enjoying your delicious casserole, store any leftovers in an airtight container in the fridge for up to 3-4 days. Be sure to let it cool to room temperature before sealing, as this helps maintain its freshness and prevents sogginess. If you plan to keep it longer, consider freezing portions for future meals!
Can I freeze the Pizza Casserole?
Yes, you can! To freeze, portion your Pizza Casserole with Biscuits and Cheese into airtight containers or freezer bags. It will keep deliciously for up to 3 months. For the best texture, thaw it in the fridge overnight before reheating. You can even freeze it unbaked, so just pop it straight into the oven from the freezer when hunger strikes, adding an extra 5-10 minutes to the baking time.
What if my casserole comes out soggy?
If your casserole is soggy, it’s likely due to excess liquid from the beef or vegetables. Always drain any extra fat and liquid from the beef mixture after cooking. If you encounter a wet casserole, allow it to cool slightly and then broil the top for a few minutes to help firm it up. You can also cut down on moisture by using less sauce or cooking the pepper beforehand to evaporate some of the water.
Is this recipe suitable for people with dietary restrictions?
Definitely! This Pizza Casserole with Biscuits and Cheese can be easily customized. For gluten-free options, use gluten-free biscuits and ensure that your sauce is free from gluten. If you or someone you’re serving has dairy allergies, try using dairy-free cheese alternatives. You can also substitute your preferred protein or skip the meat entirely for a vegetarian dish!
How can I make meal prep easier with this recipe?
To make meal prepping a breeze, assemble your casserole in advance and store it in the fridge for up to a day. You can also freeze it completely before baking. Just cover it well with foil or wrap, and when you’re ready, bake it from frozen by adding an extra 10-15 minutes of cooking time. This way, you’ll have a homemade, comforting meal ready whenever the craving hits!

Ultimate Pizza Casserole with Biscuits and Cheese for Families
Ingredients
Equipment
Method
- Preheat the Oven to 375°F (190°C) and grease a 9x13 inch baking dish with non-stick spray.
- In a skillet, cook the lean ground beef over medium heat for 3-4 minutes until crumbled and no longer pink. Season with salt and pepper, drain excess fat.
- Add diced bell peppers to the skillet and sauté for 3-5 minutes until softened. Drain any liquid and stir in the pizza sauce, warming briefly.
- Cut the Pillsbury Grands Biscuits into six pieces each and layer evenly in the greased baking dish.
- Pour the beef and vegetable mixture over the biscuit pieces, folding gently to combine.
- Sprinkle shredded mozzarella cheese and sliced turkey pepperoni evenly over the top.
- Bake uncovered for 25-30 minutes until bubbly and golden brown. Use foil if it begins to brown too quickly.
- Let cool for 5-10 minutes before slicing and serving warm.
Leave a Reply